(2006). Robustness is a term that is commonly used in publications dealing with method validation. When it is transposed into a system, it refers to the ability of tolerating perturbations that might affect the system’s functional body. ROBUSTNESS ROBUSTNESS of an analytical procedure is a measure of its capacity to remain unaffected by small, but deliberate variations in method parameters and provides an indication of its reliability during normal usage. Robustness is the capacity of a method to remain unaffected by … ... accuracy, precision, sensitivity, selectivity, robustness, ruggedness, scale of operation, analysis time, availability of equipment, and cost. Robustness is the property of being strong and healthy in constitution. extraction time. Definition Analytical Chemistry can be defined in four simple ways as: (1) the discipline in charge of “Analysis” (the fourth component of Chemistry in addition to Theory, Synthesis and ... Robustness in an analytical method is the resistance to change in its results when applied A third definition proposes that this analytical parameter is “the capacity of an analytical procedure to remain unaffected by small but deliberately introduced variations in method parameters and provides an indication of its reliability during normal usage” . 44 Analytical Chemistry 2.0 Finally, a protocol is a set of stringent guidelines specifying a proce-dure that must be followed if an agency is to accept the results. Critical Reviews in Analytical Chemistry: Vol. Also see: Analytical Method Validation pH of mobile phase. Temperature. 3-4, pp. MASSART ChemoA C, Pharmaceutical Institute, Vro'e Universiteit Brussel, Robustness The robustness of an analytical procedure is a measure of its capacity to remain unaffected by small, but deliberate, variations in method parameters and provides an indication of its reliability during normal usage. Validation has been placed within the context of the procedure, generating chemical data. 221-242. Flow rate. Robustness and Outlier Detection in Chemometrics. Examples of typical variations are : Stability of analytical solutions. This work implies that these chemistries may be significantly more robust in the digital, rather than kinetic, format. Note: Ideally, robustness should be explored during the development of the assay method. Robustness and ruggedness are frequently confused and interrelated. Robustness. developed, but their robustness is not well understood. By far the most different column makes. Method validation is a key element in the establishment of reference methods and within the assessment of a laboratory’s competence in generating dependable analytical records. It also calls for theoretical studies to predict robustness of these chemistries and, more generally, to design robust reaction architectures. 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